Inclusion complexion of ketoprofen with B-cyclodextrin and hydroxypropyl B-cyclodextrin in water and in solid state

Inclusion complexation of ketoprofen with beta -cyclodextrin[beta -CD] and hydroxypropyl beta cyclodextrin [HP beta -CD] in aqueous solutions and in the solid phase were examined by phase solubility diagrams, infrared spectroscopy, and diffraction patterns. Ketoprofen-cyclodextrin inclusion complexes were obtained applying different techniques including spray drying, freeze drying, evaporation under vacuum and co-grinding in presence and absence of water. The dissolution profile of ketoprofen was highly improved in the complexed from compared to non- treated ketoprofen or its physical mixtures with either- beta CD or HP beta-CD in the same ratio

Evaluation of ketoprofen B-cyclodextrin inclusion complex formulated into tablets, capsules and suppositories

Ketgoprofen beta Cyclodextrin [beta CD] inclusion complexes prepared by co-grinding, freeze drying and evaporation under vacuum were formulated into tablets, capsules and suppositories. The prepared ketoprofen dosage forms were evaluated with regard to their dissolution, behavior and compared to comercial ketoprofen dosage forms. Directly compressed ketoprofen beta -CD tablets showed relatively better dissolution characteristics than a commercial ketoprofen capsule dosage from. Manually filled hard gelatin capsules of either the spray dried complex or the ground mixture showed a very fast dissolution rate compared to the tested commercial ketoprofen capsules. on the other hand, suppositories containing ether the freeze dried complex or the ground mixture gave rise to a relatively faster in vitro release than those containing non-treated ketopfrofen or the tested commercial ketoprofen suppositories